{
  "metadata": {
    "fetch_date": "2026-02-03T17:25:00.000000",
    "targets": {
      "GLP1R": "ENSG00000112164",
      "GIPR": "ENSG00000010310"
    },
    "source": "Open Targets Platform API"
  },
  "data": {
    "GLP1R": {
      "ensembl_id": "ENSG00000112164",
      "symbol": "GLP1R",
      "name": "glucagon like peptide 1 receptor",
      "safety_liabilities": [
        {
          "event": "less weight gain",
          "eventId": "",
          "datasource": "ClinPGx",
          "url": "https://www.clinpgx.org/search?query=ENSG00000112164",
          "literature": null
        },
        {
          "event": "weight gain",
          "eventId": "",
          "datasource": "ClinPGx",
          "url": "https://www.clinpgx.org/search?query=ENSG00000112164",
          "literature": null
        }
      ],
      "genetic_constraint": [
        {
          "constraintType": "syn",
          "score": -0.093,
          "exp": 182.7,
          "obs": 185,
          "oe": 1.013,
          "oeUpper": 1.144,
          "upperBin": null,
          "upperRank": null,
          "interpretation": "Synonymous variants - not constrained"
        },
        {
          "constraintType": "mis",
          "score": 1.801,
          "exp": 447.3,
          "obs": 343,
          "oe": 0.767,
          "oeUpper": 0.839,
          "upperBin": null,
          "upperRank": null,
          "interpretation": "Missense variants - moderately constrained (oe < 1)"
        },
        {
          "constraintType": "lof",
          "score": 0.986,
          "exp": 41.84,
          "obs": 13,
          "oe": 0.311,
          "oeUpper": 0.494,
          "upperBin": 1,
          "upperRank": 2760,
          "interpretation": "Loss-of-function variants - highly constrained (oe = 0.31, upper bin 1)"
        }
      ]
    },
    "GIPR": {
      "ensembl_id": "ENSG00000010310",
      "symbol": "GIPR",
      "name": "gastric inhibitory polypeptide receptor",
      "safety_liabilities": [
        {
          "event": "weight gain",
          "eventId": "",
          "datasource": "ClinPGx",
          "url": "https://www.clinpgx.org/search?query=ENSG00000010310",
          "literature": null
        },
        {
          "event": "plasma insulin levels",
          "eventId": "",
          "datasource": "ClinPGx",
          "url": "https://www.clinpgx.org/search?query=ENSG00000010310",
          "literature": null
        },
        {
          "event": "plasma insulin levels and weight gain",
          "eventId": "",
          "datasource": "ClinPGx",
          "url": "https://www.clinpgx.org/search?query=ENSG00000010310",
          "literature": null
        }
      ],
      "genetic_constraint": [
        {
          "constraintType": "syn",
          "score": -0.191,
          "exp": 227.7,
          "obs": 233,
          "oe": 1.023,
          "oeUpper": 1.141,
          "upperBin": null,
          "upperRank": null,
          "interpretation": "Synonymous variants - not constrained"
        },
        {
          "constraintType": "mis",
          "score": -1.176,
          "exp": 523.3,
          "obs": 597,
          "oe": 1.141,
          "oeUpper": 1.221,
          "upperBin": null,
          "upperRank": null,
          "interpretation": "Missense variants - not constrained (oe > 1)"
        },
        {
          "constraintType": "lof",
          "score": 0.0,
          "exp": 45.4,
          "obs": 60,
          "oe": 1.321,
          "oeUpper": 1.638,
          "upperBin": 8,
          "upperRank": 15961,
          "interpretation": "Loss-of-function variants - not constrained (oe > 1, upper bin 8)"
        }
      ]
    }
  }
}