Type a claim and see where the literature stands on it. Every relevant abstract on PubMed is read, sorted by study design and plotted by year, so you can see which kinds of evidence agree and how that changed over time.
Each dot is a paper, colored by what its abstract reports
Rows are study designs, each with a verdict and a 95% interval
Every dot opens the sentence its verdict rests on
Example map
The strongest evidence here, 4 meta-analyses and systematic reviews, is split.
Randomized trials mostly go against it (24% of 37 for). Most papers with a verdict are observational studies (47), which are split.
Claim: “Hormone replacement therapy reduces the risk of coronary heart disease in postmenopausal women”
PubMed matches
593
for the search, before any reading
Read
200
top 200 by relevance
On topic
133
study the claim's question
On the map
129
sorted by study type
With a verdict
90
counted in the summaries
129 papers · stored example
For the claimMixedAgainst the claimUnclearNo result on the claimHollow: indirect evidenceConfidence
Based on this study, combined continuous hormone therapy probably makes little to no difference to the risk of a coronary event (RR 1.17, 95% CI 0.95 to 1.44; moderate-certainty evidence).
The full abstract couldn't be loaded. Read it on PubMed.
This is what the abstract reports, read by an AI model. Check the paper before relying on it. Have the PDF? Rigor Scan checks how completely it reports its methods.
Reading the map
Rows are study designs, strongest first. Reviews and commentary are shown but never counted.
Each dot is one paper, placed at its publication date. Color is what its abstract reports about the claim; stronger color means a more confident reading.
Hollow dots test the claim indirectly: another population, species or model, or a stand-in outcome. Turn on “Direct evidence only” to drop them.
A row's verdict needs at least 3 papers with a verdict. The dot and bar under it show the share for, with its 95% interval against the 50% line.
This maps what abstracts claim, not effect sizes. It is not a meta-analysis, and published literature leans toward positive findings.
Search used: Hormone replacement therapy coronary heart disease postmenopausal women, research papers only. Open it on PubMed
Take it further with K-Dense Web
This map is built from 129 abstracts. K-Dense Web can read the full papers, extract effect sizes and run the meta-analysis. Pick what to send.
The brief lists the claim, the search, each design's verdicts and the PubMed IDs on the map. K-Dense Web fetches the papers itself.
Every paper on the map
129 of 129 shown. Select a row to read its abstract.
Paper
Evidence
2025
Cochrane Database Syst Rev
Meta-analyses & systematic reviewsPubMed type
Against the claim100%
Direct
2025
JAMA Intern Med
Randomized trialsPubMed type
Against the claim76%
Direct
2024
Climacteric
Observational studiesRead from abstract
For the claim81%
Direct
2020
Circ Genom Precis Med
Observational studiesPubMed type
Mixed80%
Direct
2020
Cancer Prev Res (Phila)
Reviews & commentaryRead from abstract
Against the claim100%
Direct
2020
Menopause
Randomized trialsPubMed type
Mixed62%
Direct
2019
Prev Med Rep
Observational studiesRead from abstract
Against the claim72%
Indirect
2019
Hum Reprod Update
Meta-analyses & systematic reviewsPubMed type
Mixed95%
Direct
2019
Menopause
Observational studiesRead from abstract
Against the claim100%
Direct
2018
Menopause
Randomized trialsPubMed type
Against the claim95%
Indirect
2017
J Am Heart Assoc
Randomized trialsPubMed type
Unclear48%
Direct
2017
Climacteric
Reviews & commentaryRead from abstract
Unclear37%
Indirect
2017
Cochrane Database Syst Rev
Meta-analyses & systematic reviewsPubMed type
Against the claim84%
Direct
2016
Climacteric
Reviews & commentaryRead from abstract
Unclear58%
Indirect
2016
N Engl J Med
Randomized trialsPubMed type
Mixed96%
Indirect
2015
J Clin Endocrinol Metab
Observational studiesRead from abstract
Unclear46%
Indirect
2015
Menopause
Observational studiesRead from abstract
For the claim99%
Direct
2015
Cochrane Database Syst Rev
Meta-analyses & systematic reviewsPubMed type
Mixed84%
Direct
2014
Obstet Gynecol
Observational studiesRead from abstract
For the claim93%
Direct
2014
Ann Intern Med
Randomized trialsPubMed type
Against the claim94%
Indirect
2013
JAMA
Randomized trialsPubMed type
Against the claim74%
Direct
2012
Menopause
Observational studiesRead from abstract
Against the claim67%
Direct
2011
Arterioscler Thromb Vasc Biol
Observational studiesRead from abstract
Against the claim100%
Direct
2011
Menopause
Randomized trialsPubMed type
Unclear51%
Indirect
2010
Am Heart J
Randomized trialsPubMed type
Against the claim98%
Indirect
2010
Climacteric
Randomized trialsRead from abstract
For the claim69%
Indirect
2010
Am Heart J
Randomized trialsPubMed type
Against the claim89%
Indirect
2010
Ann Intern Med
Randomized trialsPubMed type
Against the claim71%
Direct
2009
Womens Health (Lond)
Reviews & commentaryRead from abstract
Mixed100%
Direct
2009
Am J Epidemiol
Randomized trialsPubMed type
Against the claim100%
Direct
2009
Menopause
Randomized trialsPubMed type
Against the claim95%
Indirect
2009
Menopause Int
Reviews & commentaryRead from abstract
Unclear54%
Direct
2009
Lupus
Observational studiesRead from abstract
Against the claim97%
Indirect
2008
Gynecol Endocrinol
Observational studiesRead from abstract
Against the claim98%
Direct
2008
Arch Intern Med
Randomized trialsPubMed type
Against the claim100%
Direct
2008
Epidemiology
Observational studiesRead from abstract
Against the claim69%
Direct
2008
Menopause
Observational studiesRead from abstract
Against the claim100%
Direct
2007
Am J Epidemiol
Reviews & commentaryRead from abstract
Against the claim91%
Indirect
2007
Curr Opin Cardiol
Reviews & commentaryRead from abstract
Against the claim100%
Direct
2007
N Engl J Med
Randomized trialsPubMed type
For the claim80%
Indirect
2007
Hum Reprod
Observational studiesRead from abstract
Mixed62%
Direct
2007
PLoS Med
Observational studiesRead from abstract
Mixed73%
Direct
2007
JAMA
Randomized trialsPubMed type
Mixed81%
Direct
2006
Maturitas
Randomized trialsPubMed type
Against the claim100%
Direct
2006
Menopause
Reviews & commentaryRead from abstract
Mixed71%
Indirect
2006
Arch Intern Med
Randomized trialsPubMed type
Unclear59%
Direct
2005
Menopause
Observational studiesRead from abstract
For the claim96%
Indirect
2005
Thromb Haemost
Observational studiesRead from abstract
Against the claim87%
Indirect
2005
J Womens Health (Larchmt)
Observational studiesRead from abstract
Mixed92%
Indirect
2005
Int J Cardiol
Randomized trialsRead from abstract
Against the claim97%
Indirect
2005
Korean J Intern Med
Randomized trialsRead from abstract
Mixed84%
Indirect
2005
Hypertension
Randomized trialsPubMed type
Against the claim66%
Indirect
2004
J Womens Health (Larchmt)
Observational studiesRead from abstract
Against the claim100%
Indirect
2004
J Clin Endocrinol Metab
Randomized trialsPubMed type
Against the claim99%
Indirect
2004
Am Heart J
Randomized trialsPubMed type
Unclear57%
Direct
2004
J Manag Care Pharm
Reviews & commentaryRead from abstract
Against the claim100%
Direct
2004
Gynecol Endocrinol
Randomized trialsPubMed type
For the claim73%
Indirect
2004
Prescrire Int
Reviews & commentaryRead from abstract
Against the claim100%
Direct
2004
JAMA
Randomized trialsPubMed type
Against the claim100%
Direct
2003
J Clin Endocrinol Metab
Observational studiesRead from abstract
Unclear66%
Indirect
2003
N Engl J Med
Randomized trialsPubMed type
Against the claim99%
Indirect
2003
Minerva Ginecol
Randomized trialsPubMed type
Against the claim99%
Indirect
2003
Am Heart J
Observational studiesRead from abstract
Against the claim99%
Indirect
2003
Prescrire Int
Reviews & commentaryRead from abstract
Against the claim100%
Direct
2003
Br J Gen Pract
Observational studiesRead from abstract
Against the claim100%
Direct
2003
Int J Cardiol
Observational studiesRead from abstract
For the claim89%
Indirect
2002
Lancet
Randomized trialsPubMed type
Against the claim99%
Indirect
2002
Control Clin Trials
Randomized trialsRead from abstract
No result on the claim100%
Indirect
2002
J Womens Health Gend Based Med
Observational studiesRead from abstract
Against the claim93%
Indirect
2002
Geriatrics
Reviews & commentaryRead from abstract
Against the claim100%
Direct
2002
JAMA
Randomized trialsPubMed type
Against the claim100%
Direct
2002
Circulation
Randomized trialsPubMed type
Against the claim96%
Direct
2002
Circulation
Randomized trialsRead from abstract
Against the claim99%
Indirect
2002
J Am Coll Cardiol
Randomized trialsPubMed type
Against the claim97%
Indirect
2001
Arterioscler Thromb Vasc Biol
Observational studiesRead from abstract
Mixed84%
Indirect
2001
Blood Coagul Fibrinolysis
Case reports & seriesRead from abstract
Unclear47%
Indirect
2001
Ann Intern Med
Randomized trialsPubMed type
Unclear58%
Indirect
2001
Ann Intern Med
Randomized trialsPubMed type
Unclear44%
Indirect
2001
Maturitas
Observational studiesRead from abstract
For the claim98%
Indirect
2001
Arterioscler Thromb Vasc Biol
Randomized trialsPubMed type
Against the claim99%
Indirect
2001
JAMA
Observational studiesRead from abstract
Against the claim83%
Direct
2000
Ann Intern Med
Observational studiesRead from abstract
For the claim85%
Direct
2000
Epidemiology
Observational studiesRead from abstract
Against the claim64%
Direct
2000
Cardiol Rev
Reviews & commentaryRead from abstract
Mixed100%
Direct
2000
Control Clin Trials
Randomized trialsPubMed type
No result on the claim100%
Indirect
2000
JAMA
Randomized trialsPubMed type
Mixed62%
Indirect
2000
J Gerontol A Biol Sci Med Sci
Observational studiesRead from abstract
For the claim96%
Indirect
1999
Arterioscler Thromb Vasc Biol
Randomized trialsPubMed type
Mixed69%
Indirect
1999
Metabolism
Observational studiesRead from abstract
For the claim96%
Indirect
1999
Thromb Haemost
Randomized trialsPubMed type
For the claim75%
Indirect
1999
Arterioscler Thromb Vasc Biol
Observational studiesRead from abstract
Mixed85%
Indirect
1999
Metabolism
Observational studiesRead from abstract
For the claim77%
Indirect
1998
Arterioscler Thromb Vasc Biol
Randomized trialsPubMed type
For the claim89%
Indirect
1998
J Clin Pharmacol
Observational studiesRead from abstract
For the claim83%
Indirect
1998
Diabetes Care
Observational studiesRead from abstract
For the claim79%
Indirect
1998
JAMA
Randomized trialsPubMed type
Against the claim99%
Direct
1998
Control Clin Trials
Randomized trialsPubMed type
No result on the claim100%
Indirect
1998
Am J Cardiol
Observational studiesRead from abstract
For the claim86%
Indirect
1998
J Am Coll Cardiol
Observational studiesRead from abstract
For the claim89%
Indirect
1998
Circulation
Randomized trialsPubMed type
Against the claim93%
Indirect
1998
Br J Haematol
Observational studiesRead from abstract
For the claim94%
Indirect
1998
Proc Soc Exp Biol Med
Reviews & commentaryRead from abstract
Unclear66%
Indirect
1998
Control Clin Trials
Randomized trialsPubMed type
No result on the claim100%
Direct
1998
Maturitas
Randomized trialsPubMed type
Unclear35%
Indirect
1997
Am Heart J
Observational studiesRead from abstract
For the claim85%
Direct
1997
J Am Coll Cardiol
Observational studiesRead from abstract
For the claim89%
Indirect
1997
N Engl J Med
Observational studiesRead from abstract
Unclear49%
Indirect
1997
Obstet Gynecol
Observational studiesRead from abstract
For the claim99%
Indirect
1997
Am J Cardiol
Observational studiesRead from abstract
For the claim87%
Indirect
1997
J Am Coll Cardiol
Observational studiesRead from abstract
For the claim97%
Indirect
1996
Am J Med
Reviews & commentaryRead from abstract
For the claim99%
Indirect
1996
Am J Geriatr Cardiol
Reviews & commentaryRead from abstract
No result on the claim95%
Indirect
1996
N Engl J Med
Observational studiesRead from abstract
For the claim99%
Direct
1996
J Thromb Thrombolysis
Reviews & commentaryRead from abstract
For the claim87%
Indirect
1996
Obstet Gynecol
Reviews & commentaryRead from abstract
For the claim99%
Direct
1995
Am J Public Health
Observational studiesRead from abstract
Unclear39%
Direct
1995
Lancet
Randomized trialsRead from abstract
For the claim90%
Indirect
1995
J Am Med Womens Assoc (1972)
Reviews & commentaryRead from abstract
No result on the claim100%
Indirect
1994
J Am Coll Cardiol
Animal studiesRead from abstract
Mixed62%
Indirect
1994
Circulation
Observational studiesRead from abstract
For the claim89%
Indirect
1993
Cardiovasc Res
Cell & molecular studiesRead from abstract
For the claim92%
Indirect
1993
Thromb Haemost
Observational studiesRead from abstract
For the claim79%
Indirect
1993
Br J Haematol
Observational studiesRead from abstract
Unclear44%
Indirect
1992
Womens Health Issues
Reviews & commentaryRead from abstract
For the claim79%
Indirect
1991
N Engl J Med
Observational studiesRead from abstract
For the claim100%
Direct
1990
Arch Intern Med
Observational studiesRead from abstract
Unclear59%
Indirect
1990
Obstet Gynecol
Observational studiesRead from abstract
For the claim95%
Indirect
1990
Geriatrics
Reviews & commentaryRead from abstract
For the claim96%
Indirect
1989
N Engl J Med
Observational studiesRead from abstract
For the claim71%
Indirect
1
Search PubMed
Your claim becomes a PubMed search you can edit. The top 200 papers by relevance are fetched, with retracted papers and notices removed.
2
Read every abstract
An AI model answers the same six questions of each abstract: is it on topic, which way it points (asked two ways), whether it tests the claim directly, what kind of study it is, and which sentence holds the finding.
3
Sort by design
PubMed's own publication types decide the study design where they're clear. Otherwise the model's reading of the abstract does, and the page says which.
4
Summarize with intervals
Each design gets a share for with a 95% interval. The headline is built from fixed rules over those rows, starting with the strongest design.
What it is, and isn't
A map of what published abstracts report about a claim, and how that differs by study design and over time.
Not a meta-analysis: papers aren't weighted by size or quality, and effect sizes aren't pooled.
K-Dense doesn't store or log your claims. The claim is sent with the public abstracts to be read, and the map lives in your tab.
Method v0.1 · September 23, 2026
How the map is made
Everything that decides a map is published here: the search, every question exactly as it is asked, every threshold and every rule. The launch post walks through worked examples and how to use a map.
The questions asked of every abstract
Each abstract is read on its own, with the claim beside it: { claim, paper: { title, abstract } }. The abstract is split into sentences, each prefixed with an id (S01|). The model returns a probability for every option; it doesn't write text.
1. On topic (yes or no)
“Does the paper investigate the relationship described in the claim?”
yesThe paper studies or reviews the same kind of exposure or intervention and the same kind of outcome as the claim, in any population, species or model
noThe paper is about a different question, or mentions the claim's topic only in passing
2 and 3. Verdict, asked two ways (one option)
“What do the paper's own results say about the claim?” and “Taken as a whole, which way does the paper's evidence point on the claim?”
supportsThe paper's results or conclusions agree with the claim For example: An effect in the direction the claim states; No effect, when the claim is that there is none.
contradictsThe paper's results or conclusions disagree with the claim For example: No effect or no association where the claim asserts one; An effect in the opposite direction to the claim; Harm where the claim asserts benefit.
mixedSome results agree with the claim and others disagree, for example across outcomes, doses, subgroups or time
no_resultThe paper reports no result that bears on the claim For example: A study protocol or method; A review that describes the topic without reaching a conclusion.
4. Direct evidence (yes or no)
“Does the paper test the claim directly?”
yesThe paper studies the same population, exposure or intervention, and outcome that the claim names
noThe paper uses a different population, species or laboratory model, or a stand-in exposure or outcome
5. Study type (one option)
“What kind of study is this paper?”
meta_analysisSystematic review or meta-analysis that pools results from several studies
rctRandomized controlled trial in people
observationalStudy of people without random assignment: cohort, case-control, cross-sectional, registry, database or retrospective analysis, or a non-randomized trial
case_reportCase report or case series describing individual patients
animalExperiments in live animals
in_vitroLaboratory experiments on cells, tissues or molecules without live animals
reviewNarrative review, commentary, editorial, guideline or opinion without its own pooled analysis
otherModeling, simulation, methods, protocol or anything else
6. Finding (one of the abstract's own sentences)
“Which sentence of the abstract reports this paper's own result that bears most directly on the claim?”
The options are the abstract's sentence ids, so the highlighted finding is always text the paper contains.
Search
The claim becomes PubMed search terms by dropping direction words (“reduces”, “increases”) and filler, so papers aren't missed for using a different verb. You can edit the search.
Every search adds hasabstract AND english[la]. Unless you ask for narrative reviews and commentary, it also adds NOT ((review[pt] NOT systematic[sb]) OR editorial[pt] OR comment[pt] OR letter[pt] OR news[pt]), which keeps systematic reviews.
The top 100, 200, 300 papers by PubMed Best Match are read, whichever you choose.
If PubMed doesn't recognize a search term it quietly searches without it. Claimscape stops instead and names the term, so a typo can't change the question.
Removed before reading: Retracted Publication, Retraction of Publication, Published Erratum, Expression of Concern.
Changing only the claim re-reads the same papers, so you can see how wording moves the map.
Verdicts and summaries
A paper is on the map when its on-topic answer is at least 50%, and counts as direct evidence at 50% or more.
Its verdict counts when both readings pick the same option and their average is at least 60%. Otherwise it is unclear.
Reviews and commentary are shown but never counted.
share for = (for + mixed / 2) / (for + mixed + against)
interval = Wilson score, 95%
Too few to say
Fewer than 3 papers with a verdict.
Mostly for
The lower end of the 95% interval is above 50% and the share for is at least 75%.
Leans for
The lower end of the 95% interval is above 50%.
Mostly against
The upper end of the 95% interval is below 50% and the share for is at most 25%.
Leans against
The upper end of the 95% interval is below 50%.
Split
The 95% interval includes 50%.
The headline names the verdict of the strongest design that has one, then the first other design that points the opposite way.
Study type
PubMed publication types, assigned by NLM indexers, decide the row when they are clear. Rules are checked in order and the first match wins. An abstract indexed only as “Review” moves to meta-analyses when the model reads it as one at 80% or more.