Publications

Detailed profession-specific system prompts raise token use and estimated cost per response without a consistent accuracy gain. We evaluate Scientific Agents, an open-source corpus of 503 profession-specific AGENTS.md profiles, with Gemini 3.8 Flash via OpenRouter in the Pi agent harness. We compare matched profiles with four controls: a minimal baseline ("You are a helpful assistant"), the profile's opening role sentence, a generic scientific rigor guide, and a profile from an unrelated domain. Across nine text-based science benchmarks (4,531 sampled questions, 100 matched profiles), 4,488 items completed all five conditions after API-error retries, scored with automated, rule-based grading. The average profile-baseline accuracy difference is -0.6 percentage points (95% bootstrap interval [-1.5, +0.2] across fixed tasks), and no benchmark shows a statistically clear improvement. Matched profiles produced 1.5-2.3 times as many output tokens and cost 2.2-4.5 times more per successful call. On 60 tool-using BioMysteryBench bioinformatics problems (three runs each for baseline and profile), mean solve rates were 46.7% with the profile and 56.7% at baseline, a difference of -10.0 percentage points (95% interval [-16.7, -3.3]) driven by more frequent token- and time-limit stops under the profile. Longer prompts had one unexpected operational advantage: on SuperGPQA, frequent provider API drops left the short baseline with a correct first-pass answer on only 54.0% of items, against 71.6% with the profile. Generic and mismatched prompts were about as reliable, so this gain comes from prompt length or formatting rather than domain expertise. For the tested model and tasks, loading full profession profiles by default does not improve accuracy and costs considerably more; whether selective retrieval of profile sections or open-ended scientific tasks would change this remains to be tested.

K-Dense BYOK (bring your own keys) is a free, open-source AI research assistant for scientists in any field that runs on the researcher's own computer. The researcher supplies access to a model of their choice, hosted or running locally, and the application supplies everything else: a place for the work to run, a layer of scientific scaffolding, and a complete record. Each project is an ordinary folder, so the data, the code, the results, and the record stay on a machine the researcher administers and can be read years later without the application. Three things separate it from a chat assistant or a general-purpose coding agent. It ships a library of written scientific procedures, guided workflow templates, catalogs of where research data can be found, and reviewer and writer roles the agent can hand work to. It keeps a Living Lab Notebook whose entries link into an argument and are added to but never erased. And it records what happened by watching what the agent does rather than by taking the agent's word for it, in a log the agent has no tool that can write to. That choice targets the most common failure, model overclaiming, in our earlier benchmark of nine frontier models, by making claims checkable rather than preventing them. On twenty interdisciplinary research prompts, scored under a rubric fixed in advance, K-Dense BYOK led two managed platforms on both scientific quality and research execution. Its deliverables were the only ones that recorded the software they ran in, and the only ones that usually arrived with a command that regenerates the results. One of the managed platforms ran the same frontier model and supplied neither. Those environment records were files the agent wrote, not part of the observed log, which does not yet capture the software environment itself. The code is available under the MIT license at https://github.com/K-Dense-AI/k-dense-byok.

Giving an agent a file about a named expert can supply hard-to-find material, produce a recognizable persona, or change what the agent decides. These are different claims. We test each one. mimeo is an open-source tool that finds a person's public work, checks each extracted quotation against the cached source text, and writes a file an agent can load. Eight logged builds averaged 38 model calls; the check rejects 13.2% of extracted quotations. We tested four expert files with one coding-agent harness. Knowledge access was clearest: mimeo answered all 20 obscure, quotation-heavy questions; no closed-book condition answered more than 10. Keyword search (BM25) over the same pages answered 15-17, a gap this sample cannot resolve. Grounding showed one clear benefit: personas written from model memory misstated a documented position on 1-4 of 20 answers under every grader; the plain agent and mimeo never did. Every persona was easy to spot on short open prompts, and adding task material lowered identification by 18-23 points. mimeo was no more identifiable than a from-memory profile. Judgment transfer remained unresolved because both tests hit their ceiling: every condition found 94-97% of the problems planted in engineering tasks and scored 94-100% on 16 new application scenarios. An AI-judged "sounds like the expert" score changed with the judge: two of four preferred answers based on a model's stereotype, while two found no difference on the same text. That is a caution against relying on a single AI judge. The evidence supports mimeo as a compact, inspectable reference on a person, not as a demonstrated transfer of their judgment. Toolkit and expert profiles: https://github.com/K-Dense-AI/mimeo

A language-model agent asked to analyze an experiment will usually return working code. Whether the analysis is defensible is a different question. A defensible analysis depends on procedural choices: which test the field accepts, which identifier namespace is authoritative, and which caveats must accompany a result. We present Scientific Agent Skills, an open library of 163 such procedures in 16 areas of practice, including genomics, cheminformatics, medical imaging, study design and scientific communication. Each skill is a directory built around a versioned, human-readable instruction file. An agent loads the file only when a task calls for it; the directory often also contains reference material and runnable scripts. We report no task-level evaluation and no host selection rate. Openly licensed and available at https://github.com/K-Dense-AI/scientific-agent-skills.

Benchmarks for scientific artificial intelligence are mostly written to be scored: multiple-choice questions, curated agent tasks with reference solutions, or simulators with a known generative structure. Real scientific requests arrive differently. They are underspecified, they carry attachments, and lack ground truth. We report K-Bench 01, an evaluation built from first-turn requests sampled from live user traffic on K-Dense Web and run end to end by nine frontier models in identical sandboxes, yielding 1,602 completed agent runs. Three blinded language-model judges scored every run against an eight-dimension rubric. On a rubric whose 8-anchor instructs judges that a domain scientist would accept the work with minor edits, no model clears the line under all three judges. gpt-5.6-sol has the highest pooled mean, 8.04, but its 95% interval [7.80, 8.23] spans the threshold, and two of the three judges rank claude-opus-5 first instead. We therefore report the ordering of systems as the reproducible quantity, the absolute level as an attribute of the instrument, and the top of the table as unresolved. Across all 39,934 scored judgments — the eight dimension scores plus a holistic overall for each assessment, excluding not-applicable cells — 47.6% fall below the 8-point threshold. Difficulty is not uniform across the rubric: scientific accuracy averages 6.22 against 7.33 for communication, on identical denominators and in the same direction within every one of the nine models. The single leading failure tag is overclaiming, on 31.4% of assessments. We argue that the informative quantity for scientific agents is not a leaderboard position but the joint distribution of what was delivered, what was claimed, and what artifacts were produced.

Scientific discovery has long relied on human creativity, with computation limited to analysis. Here we report an AI-guided system, K-Dense, that accelerates hypothesis testing and delivers robust scientific discoveries. Trained on ARCHS4 (57,584 samples, 28 tissues, 1,039 cohorts, ages 1-114), the unified ensemble clock achieved R² = 0.854 and MAE = 4.26 years — while uniquely providing calibrated confidence intervals. This self-aware design flags predictions made at transitional or extreme ages, where biological heterogeneity peaks, suggesting clinical utility for uncertainty itself. Development revealed stage-specific markers, including CDKN2A/p16 (senescence), AMPD3 (muscle wasting), MIR29B2CHG (progeroid traits), and SEPTIN3 (neurodegeneration resistance). Sliding-window analysis across 85 overlapping ranges uncovered wave-like shifts in gene importance, showing that transcriptomic aging signatures evolve continuously, not discretely. By transforming biological age assessment from static point estimates to calibrated predictions with explicit uncertainty, this approach establishes reliable and interpretable clocks. Beyond the clock itself, K-Dense demonstrates how guided AI can compress months of exploration into weeks, pointing toward a scalable framework for accelerated scientific discovery.

The complexity of modern bioinformatics analysis has created a critical gap between data generation and developing scientific insights. While large language models (LLMs) have shown promise in scientific reasoning, they remain fundamentally limited when dealing with real-world analytical workflows that demand iterative computation, tool integration and rigorous validation. We introduce K-Dense Analyst, a hierarchical multi-agent system that achieves autonomous bioinformatics analysis through a dual-loop architecture. K-Dense Analyst, part of the broader K-Dense platform, couples planning with validated execution using specialized agents to decompose complex objectives into executable, verifiable tasks within secure computational environments. On BixBench, a comprehensive benchmark for open-ended biological analysis, K-Dense Analyst achieves 29.2% accuracy, surpassing the best-performing language model (GPT-5) by 6.3 percentage points, representing nearly 27% improvement over what is widely considered the most powerful LLM available. Remarkably, K-Dense Analyst achieves this performance using Gemini 2.5 Pro, which attains only 18.3% accuracy when used directly, demonstrating that our architectural innovations unlock capabilities far beyond the underlying model's baseline performance. Our insights demonstrate that autonomous scientific reasoning requires more than enhanced language models, it demands purpose-built systems that can bridge the gap between high-level scientific objectives and low-level computational execution. These results represent a significant advance toward fully autonomous computational biologists capable of accelerating discovery across the life sciences.