Topic

Structural Biology

2 K-Dense articles on Structural Biology — research automation, benchmarks, and case studies from the K-Dense team.

Where Structure Stops Explaining TP53: K-Dense Web Maps 3,629 Missense Mutations Against Function and ClinVar
K-Dense Web tested all 3,629 TP53 DNA-binding domain missense variants against structure, function and ClinVar, and exposed a circular pathogenicity benchmark.
By Darshil Patel
September 27, 202613 min read
Reading AlphaFold Confidence Correctly: A Structural Census of All 21 Human CDKs
K-Dense Web analyzed AlphaFold models for all 21 human CDKs and found that chain-level confidence says almost nothing about the kinase domain drug hunters target.
By Darshil Patel
September 25, 202610 min read

Where Structure Stops Explaining TP53: K-Dense Web Maps 3,629 Missense Mutations Against Function and ClinVar