Meet the Fellows Running End-to-End Agentic Science
Hypothesis-to-Evidence Grant fellows Joy-Yan Lam, Alexander Reading, and Daniel Pascal will pilot closed-loop experimentation with K-Dense and Litmus Science.
3 min read
Topic
Research
48 K-Dense articles on Research — research automation, benchmarks, and case studies from the K-Dense team.
Same Cells, Different Answers: K-Dense Web Re-Tests the Kang 2018 Interferon Response for Pseudoreplication
K-Dense Web reproduced the Kang 2018 interferon PBMC study three ways and found 2,632 cell-level effects that fade once each donor counts as one replicate.
13 min readIf AI Wants the Public's Trust, It Should Cure Something
Public fear of AI keeps rising, and much of it is earned. The way back is not another math milestone. It is AI that visibly improves health and science.
20 min readIntroducing Citation Telephone: Trace a Cited Claim Back to Its Source
Citation Telephone follows a cited claim back through the papers it cites, reads each one, and shows where the claim came from and what changed on the way.
21 min readWhere Structure Stops Explaining TP53: K-Dense Web Maps 3,629 Missense Mutations Against Function and ClinVar
K-Dense Web tested all 3,629 TP53 DNA-binding domain missense variants against structure, function and ClinVar, and exposed a circular pathogenicity benchmark.
13 min readIntroducing Claimscape: See Where the Literature Stands on Any Claim
Claimscape reads the most relevant PubMed abstracts on a claim, sorts them by study design and plots them over time, so you can see where the evidence stands.
10 min readIntroducing Rigor Scan: A Free Reporting Check for Research Papers, Built on Jev
Rigor Scan checks how completely a paper reports its design, statistics, materials, data and claims, using Jev to tie every result to the sentence behind it.
14 min readK-Dense BYOK on CompBioBench: Three Models, One Harness
Gemini 3.8 Flash scored 94% and GPT-5.6 SOL 92% on CompBioBench v1, a statistical tie. DeepSeek V4 Pro scored 81% on the same K-Dense BYOK harness (n=100).
16 min readIntroducing K-Bench 01: Nine Frontier Models, 178 Real Scientific Tasks, and a Lot of Confident Wrong Answers
K-Bench 01 is our internal benchmark built from 178 real scientific tasks. Nine frontier models ran them end to end; only one clears the acceptability bar.
11 min readHow to Use Multica for Scientific Research
Real research runs on a self-hosted Multica workspace using K-Dense Scientific Agent Skills: trials, variants, literature, and cross-model review.
24 min readK-Dense Web and Litmus Science: Closing the Loop from Hypothesis to Experiment
K-Dense and Litmus Science are connecting AI-powered research with on-demand lab execution, helping scientists move from questions to evidence faster.
6 min readAI Co-Scientists, Answered: 20 Questions from a Live Session with a University Research Center
Twenty questions from a live session with a university multiomics center on what K-Dense does, where AI for science helps today, and where it still falls short.
10 min readK-Dense Web vs. Claude Science: K-Dense Leads on Execution and Overall Score
A 20-task benchmark found K-Dense Web stronger at producing auditable research bundles, while Claude Science held a narrow scientific-quality lead.
24 min readBenchmarking Google's Omni Flash for Scientific Video
A 35-case K-Dense benchmark of Google's Omni Flash shows stunning scientific video quality, but unreliable text, physics, and factual correctness.
46 min readBenchmarking Nano Banana 2 Lite for Scientific Image Generation
A 240-image benchmark of four scientific image models shows Nano Banana 2 Lite is fastest, while GPT Image 2 still leads on raw figure quality.
45 min readAI Scientists Need Lab Escape Rooms, Not More Exams
The next AI scientist benchmark should be a lab escape room: a fresh hidden world, limited probes, real evidence, and no place for science theater to hide.
13 min readBenchmarking NVIDIA BioNeMo Agent Toolkit Skills for NIM microservices
A controlled benchmark of 10 NVIDIA BioNeMo Agent Toolkit skills for NIM microservices shows where skills win: routing, cost, scale, and weak-model reliability.
17 min readReproduction, Not Generation, Is AI's Killer App for Science
AI is flooding science with claims no one can check. The quieter story: agents now reproduce most published findings — and that is the bigger deal.
8 min readCan an AI Agent Run Your Mass Spec Pipeline? Benchmarking the PyOpenMS Skill
A reproducible 250-run study of feature detection, adduct grouping, quantification, and identification, run by an AI agent with and without the pyOpenMS skill.
14 min readThe Week Science Models Became Real
Fable 5 and GPT-Rosalind show frontier AI moving into scientific workflows. The next bottleneck is not intelligence, but evidence.
9 min readBeyond RDKit: Benchmarking the Rowan Agent Skill Against Experiment
A reproducible study of pKa, logD, tautomers, ADME, and docking run by an AI agent with the Rowan skill, measured against RDKit and experimental ground truth.
9 min readThe Model Is No Longer the Bottleneck
Anthropic showed a general model can rival ChemDraw at NMR. The real story for scientists: the bottleneck has moved from the model to the workflow around it.
6 min readThe AI Co-Scientist Is Here. The Bottleneck Is Verification.
AI agents are moving into real scientific workflows. The question for working scientists is not whether they are powerful, but whether they are verifiable.
8 min readYour AI Assistant Reasons Like a Generalist. Science Needs a Specialist.
Scientific Agents: 503 open-source AGENTS.md profiles that teach any AI agent to reason like a senior practitioner in a specific science or engineering field.
7 min readOne Skill, 78 Databases: Why We Didn't Build 78 Skills
One Agent Skill gives a research agent 78 public scientific and economic databases. Here is the design argument, with real token and routing benchmarks.
12 min readIntroducing Science Superpowers: Scientific Discipline for Your Research Agent
Our new open source methodology makes AI research agents pre-register hypotheses, work reproducibly, and verify before they claim. Pre-registration over TDD.
6 min readToward Smarter Scientific Search: Exa Joins the Scientific Agent Skills Library
Exa is now integrated into K-Dense's Scientific Agent Skills library, bringing neural web search and URL extraction to AI-driven scientific research.
3 min readMapping the RAS Mutation Landscape in Pancreatic Cancer with K-Dense Web
K-Dense Web analyzed global RAS mutation prevalence, drug eligibility, statistics, and the clinical-trial landscape in pancreatic cancer (PDAC).
13 min readThe Virus in the Dust: How K-Dense Web Can Accelerate Hantavirus Research
A practical look at how K-Dense Web can help researchers synthesize hantavirus literature, surveillance, ecology, and public health evidence.
11 min readWhat 116 Declassified UAP Files Actually Say
K-Dense Web analyzed 116 declassified UAP files in one prompt, producing a 60-page report separating aerial activity from extraterrestrial evidence.
10 min readWhat K-Dense Web Actually Saves: A 67-Case ROI Audit
K-Dense Web ROI audit across 67 public use cases: $3.08M of analyst work delivered by K-Dense Web plus a human for $5,670 in credits.
9 min readAI Co-Scientist, Not AI Scientist: Why the Name Matters
Why we put the hyphen in front of every product we build. The case, from Benchling to AlphaFold to Polanyi, for keeping the human scientist front and center.
15 min readScience is Multimodal: K-Dense and NVIDIA on Nemotron 3 Nano Omni
K-Dense is evaluating Nemotron 3 Nano Omni — NVIDIA's new open omni-modal model that unifies vision, audio, and language for — agentic scientific workflows.
14 min readIntroducing Pantheon: One Question, 80 Voices
Pantheon is a free K-Dense app that sends one research question to 80 AI personas, streaming diverse perspectives with cited sources and consensus.
5 min readIntroducing mimeo and 80+ Mimeographs: Clone an Expert's Way of Thinking Into Your Agent
mimeo distills how great minds like Jobs, Buffett, and Wittgenstein reason into a SKILL.md or AGENTS.md your agent can load, with 80+ experts ready today.
10 min readSecurity in the Science Agent Era: What Every Lab Needs to Know Before Installing Skills
Skills are executable research code with a personality. A practical guide to prompt-injection risks, poisoned SKILL.md files, auditing, and version pinning.
17 min readThe Sandboxed AI Scientist: Pairing NVIDIA OpenShell with Scientific Agent Skills
Pair NVIDIA OpenShell's policy-governed runtime with Scientific Agent Skills to run autonomous research agents that are highly capable and genuinely safe.
13 min readK-Dense Web Scores 90.0% on BixBench-Verified-50
K-Dense Web scored 45/50 on BixBench-Verified-50, a cleaned biology-agent benchmark designed to separate real model mistakes from benchmark noise.
4 min readK-Dense Web vs OpenAI Prism: Task Execution vs Writing Assistance
K-Dense Web vs OpenAI Prism: Prism helps you write papers, while K-Dense Web does the research. See why the distinction matters and how to use them together.
5 min readAutonomous Drug Discovery: Mining 700,000 Natural Products for Antimicrobial Candidates
How K-Dense Web autonomously processed the COCONUT database to identify 50 prioritized antimicrobial candidates using unsupervised machine learning.
3 min readAutonomous Medical Device Safety Analysis: Mining 10,000 ICD Adverse Events from the FDA MAUDE Database
K-Dense Web autonomously analyzed 10,000 ICD failure reports from the FDA MAUDE database using NLP and statistics, revealing manufacturer-specific patterns.
5 min readAgent Skills: The Final Piece for AI-Powered Scientific Research
Agent Skills close the gap between raw AI intelligence and domain expertise, adding 140 open-source capabilities to AI scientific research workflows.
8 min readK-Dense Web vs ChatGPT: Why Traditional AI Assistants Fall Short for Research
A detailed comparison of K-Dense Web and ChatGPT showing why autonomous task execution beats conversational AI for any complex work.
4 min readK-Dense Web vs Claude Code: Different Tools for Different Jobs
K-Dense Web is a multi-agent system orchestrating Opus 4.5, Gemini 3 Pro, and Claude Code on a high-compute backend for complex end-to-end workflows.
4 min readK-Dense Web vs Scientific Agent Skills: Why We Built Both (And Which One You Should Use)
K-Dense Web vs Scientific Agent Skills: our open-source skills give researchers AI tools; K-Dense Web adds more skills, agents, cloud compute, and zero setup.
8 min readAgentic Data Scientist: An Open Source AI That Actually Does the Analysis
Agentic Data Scientist is a free, open-source multi-agent framework that plans, runs, and validates full data science workflows autonomously.
By Orion Li
3 min readClaude Scientific Writer: Our Open Source Tool for AI-Powered Research Writing
Claude Scientific Writer is a free, open-source tool combining deep research with publication-ready papers, grants, posters, and clinical reports.
2 min readIntroducing K-Dense Web: Research. Analyze. Synthesize. for Complex Research
Learn how K-Dense Web transforms complex research tasks into automated workflows, delivering publication-ready results across science, finance, and engineering.
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